ABSTRACT
The synthesis of some salicylate and p-chlorobenzoate esters of alpha gamma-diethers of glycerol is described. The structure of the compounds is confirmed by spectroscopic methods. Some of the compounds are tested pharmacologically and the results are included
Subject(s)
Chemistry, PharmaceuticalABSTRACT
Two seriales of alpha-y-diethers of glycerol was synthesized as analogues to mephenesin. These compounds were synthesized for the pharmacodynamic study of the effect of substituting the O-methyl group of mephenesin by the more soluble basic substituted acylamino moieties. The skeletal muscle relaxant and tranquilizing activities of five of these compounds were tested in mice and results are included
Subject(s)
Muscle Relaxants, Central , Chemistry, PharmaceuticalABSTRACT
The synthesis of some substituted pyrazolone derivatives having in position-4 an imidazole ring in which the isoureido moiety is partially featured. The analgesic activity of some of these compounds were tested in mice and results are included